# Copyright © 1996-2007 SRI International, Marine Biological Laboratory, DoubleTwist Inc., The Institute for Genomic Research, J. Craig Venter Institute, University of California at San Diego, and UNAM. All Rights Reserved. # # # Please see the license agreement regarding the use of and distribution of this file. # The format of this file is defined at http://bioinformatics.ai.sri.com/ptools/flatfile-format.html . # # Species: E. coli K-12 # Database: EcoCyc # Version: 11.5 # File Name: regulons.dat # Date and time generated: August 6, 2007, 17:32:25 # # Attributes: # UNIQUE-ID # TYPES # COMMON-NAME # ACTIVATORS-ALLOSTERIC-OF # ACTIVATORS-NONALLOSTERIC-OF # ACTIVATORS-UNKMECH-OF # APPEARS-IN-BINDING-REACTIONS # AROMATIC-RINGS # ATOM-CHARGES # ATOM-CHIRALITY # CATALYZES # CHARGE # CHEMICAL-FORMULA # CITATIONS # COFACTORS-OF # COFACTORS-OR-PROSTHETIC-GROUPS-OF # COMMENT # COMPONENT-COEFFICIENTS # COMPONENT-OF # COMPONENTS # CREDITS # DATA-SOURCE # DBLINKS # DNA-FOOTPRINT-SIZE # FEATURES # FUNCTIONAL-ASSIGNMENT-COMMENT # FUNCTIONAL-ASSIGNMENT-STATUS # GENE # GO-TERMS # INHIBITORS-ALLOSTERIC-OF # INHIBITORS-COMPETITIVE-OF # INHIBITORS-IRREVERSIBLE-OF # INHIBITORS-NONCOMPETITIVE-OF # INHIBITORS-OTHER-OF # INHIBITORS-UNCOMPETITIVE-OF # INHIBITORS-UNKMECH-OF # INSTANCE-NAME-TEMPLATE # ISOZYME-SEQUENCE-SIMILARITY # LOCATIONS # MODIFIED-FORM # MOLECULAR-WEIGHT # MOLECULAR-WEIGHT-EXP # MOLECULAR-WEIGHT-KD # MOLECULAR-WEIGHT-SEQ # N+1-NAME # N-1-NAME # N-NAME # NEIDHARDT-SPOT-NUMBER # PI # PROSTHETIC-GROUPS-OF # REGULATED-BY # REGULATES # SPECIES # SPLICE-FORM-INTRONS # STRUCTURE-BONDS # SYMMETRY # SYNONYMS # UNMODIFIED-FORM # UNIQUE-ID - MONOMER0-562 TYPES - Protein-Small-Molecule-Complexes COMMON-NAME - GlcC-Glycolate transcriptional dual regulator COMMENT - ArgR is a protein that negatively controls the expression of arginine biosynthesis in addition to the carAB operon. ArgR is also essential in the resolution of plasmid ColE1 multimers during replication through cer-mediated site-specific recombination. It belongs to the ArgR family. COMPONENTS - G7546-MONOMER COMPONENTS - GLYCOLLATE DBLINKS - (MODBASE "P0ACL5" NIL |pkarp| 3355444115 NIL NIL) DBLINKS - (SWISSMODEL "P0ACL5" NIL |pkarp| 3355444115 NIL NIL) DBLINKS - (PFAM "PF00392" IN-FAMILY |pkarp| 3346700381 NIL NIL) DBLINKS - (UNIPROT "P0ACL5" NIL |pkarp| 3343984403 NIL NIL) DBLINKS - (REFSEQ "NP_417454" NIL NIL NIL NIL NIL) DNA-FOOTPRINT-SIZE - 15 MOLECULAR-WEIGHT-KD - 28.82613199999999 MOLECULAR-WEIGHT-SEQ - 28.82613199999999 REGULATES - REG0-6036 REGULATES - REG0-6030 SYMMETRY - :INVERTED-REPEAT SYNONYMS - B2980 SYNONYMS - YghN SYNONYMS - GlcC SYNONYMS - GlcC-glycolate // UNIQUE-ID - MONOMER0-2487 TYPES - Protein-Small-Molecule-Complexes COMMON-NAME - Zur-Zn2+ COMPONENTS - EG11929-MONOMER COMPONENTS - ZN+2 DBLINKS - (PFAM "PF01475" IN-FAMILY |pkarp| 3346700432 NIL NIL) DNA-FOOTPRINT-SIZE - 23 REGULATES - REG0-6233 REGULATES - REG0-6230 SYNONYMS - ZnuR SYNONYMS - YjbK SYNONYMS - B4046 SYNONYMS - Zur // UNIQUE-ID - MONOMER0-2421 TYPES - Protein-Small-Molecule-Complexes COMMON-NAME - PrpR-2-methylcitrate COMPONENTS - G6195-MONOMER COMPONENTS - CPD-622 DBLINKS - (PFAM "PF06506" IN-FAMILY |pkarp| 3346700316 NIL NIL) DNA-FOOTPRINT-SIZE - 24 REGULATES - REG0-6315 REGULATES - REG0-6102 SYMMETRY - :INVERTED-REPEAT SYNONYMS - B0330 SYNONYMS - YahP SYNONYMS - PrpR // UNIQUE-ID - MONOMER0-2221 TYPES - Protein-Small-Molecule-Complexes COMMON-NAME - AllS-allantoin COMPONENTS - G6274-MONOMER COMPONENTS - ALLANTOIN DBLINKS - (PFAM "PF00126" IN-FAMILY |pkarp| 3346700318 NIL NIL) REGULATES - REG0-6081 SYNONYMS - YbbS SYNONYMS - B0504 SYNONYMS - AllS // UNIQUE-ID - MONOMER0-183 TYPES - Protein-Small-Molecule-Complexes COMMON-NAME - FhlA-Formate transcriptional activator CITATIONS - 8034727 CITATIONS - 8034727:EV-EXP-IDA-PURIFIED-PROTEIN:3342461042:martin CITATIONS - 8034727:EV-EXP-IGI-FUNC-COMPLEMENTATION:3342461680:martin COMMENT - FhlA is the transcriptional activator that directly controls the hycABCDEFGHI operon in the absence of molybdate, which is involved in the induction of formate hydrogen-lyase. In the presence of formate, it activates the transcription of sigma 54 dependent promoters. /It belongs to the EBP family of transcriptional regulators. / /Regulation has been described |CITS: [12753181]|. FhlA is subject to post-transcriptional regulation by the sRNA OxyS |CITS: [12753181]|. / /Review: |CITS: [12753181]|. COMPONENTS - PD02936 COMPONENTS - FORMATE DBLINKS - (MODBASE "P19323" NIL |pkarp| 3355444115 NIL NIL) DBLINKS - (SWISSMODEL "P19323" NIL |pkarp| 3355444115 NIL NIL) DBLINKS - (PFAM "PF01590" IN-FAMILY |pkarp| 3346700372 NIL NIL) DBLINKS - (UNIPROT "P19323" NIL |pick| 3277847086) DBLINKS - (REFSEQ "NP_417211" NIL NIL NIL NIL NIL) DNA-FOOTPRINT-SIZE - 40 MOLECULAR-WEIGHT-KD - 78.46782599999979 MOLECULAR-WEIGHT-SEQ - 78.46782599999979 REGULATES - REG0-5778 REGULATES - REG0-5776 REGULATES - REG0-5773 REGULATES - REG0-5017 REGULATES - REG0-4853 SYMMETRY - :INVERTED-REPEAT SYNONYMS - Fhl SYNONYMS - FhlA SYNONYMS - FhlA-formate SYNONYMS - B2731 // UNIQUE-ID - MONOMER0-1781 TYPES - Protein-Small-Molecule-Complexes COMMON-NAME - NikR-Ni transcriptional repressor COMMENT - NikR is the nickel-responsive repressor of the nikABCDER operon, which encodes a nickel-specific transport system |CITS:[9882686] [17397155]|. It is a member of the ribbon-helix-helix family of transcription factors |CITS:[10595554]|. / /The NikR dimer/tetramer contains both high-affinity and low-affinity nickel-binding sites |CITS:[12401490] [17397155]|; saturation of the high-affinity binding sites may lead to substantial binding to the nik operator, while nickel-binding to the low-affinity sites leads to a large increase in operator binding and an increased footprint size of NikR |CITS:[12401498]|. DNA binding regulates coordination of nickel in NikR |CITS:[12524532]|. / /The NikR protein can bind to a variety of divalent metal ions in addition to nickel; however, nickel binding selectively stabilizes the metal-protein complex |CITS:[15287729]|. The enhanced DNA binding affinity of the NikR-metal complex is also selective for nickel |CITS:[15287730]|. / /Crystal structures of the apoprotein and the C-terminal domain containing nickel have been solved. Four nickel-binding sites are located at the tetramer interface of the C-terminal regulatory domain |CITS:[12970756]|. / /Review: |CITS:[10648098]| COMPONENTS - EG11519-MONOMER COMPONENTS - NI+2 DBLINKS - (PDB "2HZV" NIL |keseler| 3376247248 NIL NIL) DBLINKS - (PDB "2HZA" NIL |keseler| 3376247248 NIL NIL) DBLINKS - (PFAM "PF01402" IN-FAMILY |pkarp| 3346700403 NIL NIL) DNA-FOOTPRINT-SIZE - 28 MOLECULAR-WEIGHT-KD - 15.09376200000001 MOLECULAR-WEIGHT-SEQ - 15.09376200000001 REGULATES - REG0-4827 SYMMETRY - :INVERTED-REPEAT SYNONYMS - B3481 SYNONYMS - YhhG SYNONYMS - NikR //