# Copyright © 1996-2007 SRI International, Marine Biological Laboratory, DoubleTwist Inc., The Institute for Genomic Research, J. Craig Venter Institute, University of California at San Diego, and UNAM. All Rights Reserved.
#
#
# Please see the license agreement regarding the use of and distribution of this file.
# The format of this file is defined at http://bioinformatics.ai.sri.com/ptools/flatfile-format.html .
#
# Species: E. coli K-12
# Database: EcoCyc
# Version: 11.5
# File Name: regulons.dat
# Date and time generated: August 6, 2007, 17:32:25
#
# Attributes:
# UNIQUE-ID
# TYPES
# COMMON-NAME
# ACTIVATORS-ALLOSTERIC-OF
# ACTIVATORS-NONALLOSTERIC-OF
# ACTIVATORS-UNKMECH-OF
# APPEARS-IN-BINDING-REACTIONS
# AROMATIC-RINGS
# ATOM-CHARGES
# ATOM-CHIRALITY
# CATALYZES
# CHARGE
# CHEMICAL-FORMULA
# CITATIONS
# COFACTORS-OF
# COFACTORS-OR-PROSTHETIC-GROUPS-OF
# COMMENT
# COMPONENT-COEFFICIENTS
# COMPONENT-OF
# COMPONENTS
# CREDITS
# DATA-SOURCE
# DBLINKS
# DNA-FOOTPRINT-SIZE
# FEATURES
# FUNCTIONAL-ASSIGNMENT-COMMENT
# FUNCTIONAL-ASSIGNMENT-STATUS
# GENE
# GO-TERMS
# INHIBITORS-ALLOSTERIC-OF
# INHIBITORS-COMPETITIVE-OF
# INHIBITORS-IRREVERSIBLE-OF
# INHIBITORS-NONCOMPETITIVE-OF
# INHIBITORS-OTHER-OF
# INHIBITORS-UNCOMPETITIVE-OF
# INHIBITORS-UNKMECH-OF
# INSTANCE-NAME-TEMPLATE
# ISOZYME-SEQUENCE-SIMILARITY
# LOCATIONS
# MODIFIED-FORM
# MOLECULAR-WEIGHT
# MOLECULAR-WEIGHT-EXP
# MOLECULAR-WEIGHT-KD
# MOLECULAR-WEIGHT-SEQ
# N+1-NAME
# N-1-NAME
# N-NAME
# NEIDHARDT-SPOT-NUMBER
# PI
# PROSTHETIC-GROUPS-OF
# REGULATED-BY
# REGULATES
# SPECIES
# SPLICE-FORM-INTRONS
# STRUCTURE-BONDS
# SYMMETRY
# SYNONYMS
# UNMODIFIED-FORM
#
UNIQUE-ID - MONOMER0-562
TYPES - Protein-Small-Molecule-Complexes
COMMON-NAME - GlcC-Glycolate transcriptional dual regulator
COMMENT - ArgR is a protein that negatively controls the expression of arginine biosynthesis in addition to the carAB operon. ArgR is also essential in the resolution of plasmid ColE1 multimers during replication through cer-mediated site-specific recombination. It belongs to the ArgR family.
COMPONENTS - G7546-MONOMER
COMPONENTS - GLYCOLLATE
DBLINKS - (MODBASE "P0ACL5" NIL |pkarp| 3355444115 NIL NIL)
DBLINKS - (SWISSMODEL "P0ACL5" NIL |pkarp| 3355444115 NIL NIL)
DBLINKS - (PFAM "PF00392" IN-FAMILY |pkarp| 3346700381 NIL NIL)
DBLINKS - (UNIPROT "P0ACL5" NIL |pkarp| 3343984403 NIL NIL)
DBLINKS - (REFSEQ "NP_417454" NIL NIL NIL NIL NIL)
DNA-FOOTPRINT-SIZE - 15
MOLECULAR-WEIGHT-KD - 28.82613199999999
MOLECULAR-WEIGHT-SEQ - 28.82613199999999
REGULATES - REG0-6036
REGULATES - REG0-6030
SYMMETRY - :INVERTED-REPEAT
SYNONYMS - B2980
SYNONYMS - YghN
SYNONYMS - GlcC
SYNONYMS - GlcC-glycolate
//
UNIQUE-ID - MONOMER0-2487
TYPES - Protein-Small-Molecule-Complexes
COMMON-NAME - Zur-Zn2+
COMPONENTS - EG11929-MONOMER
COMPONENTS - ZN+2
DBLINKS - (PFAM "PF01475" IN-FAMILY |pkarp| 3346700432 NIL NIL)
DNA-FOOTPRINT-SIZE - 23
REGULATES - REG0-6233
REGULATES - REG0-6230
SYNONYMS - ZnuR
SYNONYMS - YjbK
SYNONYMS - B4046
SYNONYMS - Zur
//
UNIQUE-ID - MONOMER0-2421
TYPES - Protein-Small-Molecule-Complexes
COMMON-NAME - PrpR-2-methylcitrate
COMPONENTS - G6195-MONOMER
COMPONENTS - CPD-622
DBLINKS - (PFAM "PF06506" IN-FAMILY |pkarp| 3346700316 NIL NIL)
DNA-FOOTPRINT-SIZE - 24
REGULATES - REG0-6315
REGULATES - REG0-6102
SYMMETRY - :INVERTED-REPEAT
SYNONYMS - B0330
SYNONYMS - YahP
SYNONYMS - PrpR
//
UNIQUE-ID - MONOMER0-2221
TYPES - Protein-Small-Molecule-Complexes
COMMON-NAME - AllS-allantoin
COMPONENTS - G6274-MONOMER
COMPONENTS - ALLANTOIN
DBLINKS - (PFAM "PF00126" IN-FAMILY |pkarp| 3346700318 NIL NIL)
REGULATES - REG0-6081
SYNONYMS - YbbS
SYNONYMS - B0504
SYNONYMS - AllS
//
UNIQUE-ID - MONOMER0-183
TYPES - Protein-Small-Molecule-Complexes
COMMON-NAME - FhlA-Formate transcriptional activator
CITATIONS - 8034727
CITATIONS - 8034727:EV-EXP-IDA-PURIFIED-PROTEIN:3342461042:martin
CITATIONS - 8034727:EV-EXP-IGI-FUNC-COMPLEMENTATION:3342461680:martin
COMMENT - FhlA is the transcriptional activator that directly controls the hycABCDEFGHI operon in the absence of molybdate, which is involved in the induction of formate hydrogen-lyase. In the presence of formate, it activates the transcription of sigma 54 dependent promoters.
/It belongs to the EBP family of transcriptional regulators.
/
/Regulation has been described |CITS: [12753181]|. FhlA is subject to post-transcriptional regulation by the sRNA OxyS |CITS: [12753181]|.
/
/Review: |CITS: [12753181]|.
COMPONENTS - PD02936
COMPONENTS - FORMATE
DBLINKS - (MODBASE "P19323" NIL |pkarp| 3355444115 NIL NIL)
DBLINKS - (SWISSMODEL "P19323" NIL |pkarp| 3355444115 NIL NIL)
DBLINKS - (PFAM "PF01590" IN-FAMILY |pkarp| 3346700372 NIL NIL)
DBLINKS - (UNIPROT "P19323" NIL |pick| 3277847086)
DBLINKS - (REFSEQ "NP_417211" NIL NIL NIL NIL NIL)
DNA-FOOTPRINT-SIZE - 40
MOLECULAR-WEIGHT-KD - 78.46782599999979
MOLECULAR-WEIGHT-SEQ - 78.46782599999979
REGULATES - REG0-5778
REGULATES - REG0-5776
REGULATES - REG0-5773
REGULATES - REG0-5017
REGULATES - REG0-4853
SYMMETRY - :INVERTED-REPEAT
SYNONYMS - Fhl
SYNONYMS - FhlA
SYNONYMS - FhlA-formate
SYNONYMS - B2731
//
UNIQUE-ID - MONOMER0-1781
TYPES - Protein-Small-Molecule-Complexes
COMMON-NAME - NikR-Ni transcriptional repressor
COMMENT - NikR is the nickel-responsive repressor of the nikABCDER operon, which encodes a nickel-specific transport system |CITS:[9882686] [17397155]|. It is a member of the ribbon-helix-helix family of transcription factors |CITS:[10595554]|.
/
/The NikR dimer/tetramer contains both high-affinity and low-affinity nickel-binding sites |CITS:[12401490] [17397155]|; saturation of the high-affinity binding sites may lead to substantial binding to the nik operator, while nickel-binding to the low-affinity sites leads to a large increase in operator binding and an increased footprint size of NikR |CITS:[12401498]|. DNA binding regulates coordination of nickel in NikR |CITS:[12524532]|.
/
/The NikR protein can bind to a variety of divalent metal ions in addition to nickel; however, nickel binding selectively stabilizes the metal-protein complex |CITS:[15287729]|. The enhanced DNA binding affinity of the NikR-metal complex is also selective for nickel |CITS:[15287730]|.
/
/Crystal structures of the apoprotein and the C-terminal domain containing nickel have been solved. Four nickel-binding sites are located at the tetramer interface of the C-terminal regulatory domain |CITS:[12970756]|.
/
/Review: |CITS:[10648098]|
COMPONENTS - EG11519-MONOMER
COMPONENTS - NI+2
DBLINKS - (PDB "2HZV" NIL |keseler| 3376247248 NIL NIL)
DBLINKS - (PDB "2HZA" NIL |keseler| 3376247248 NIL NIL)
DBLINKS - (PFAM "PF01402" IN-FAMILY |pkarp| 3346700403 NIL NIL)
DNA-FOOTPRINT-SIZE - 28
MOLECULAR-WEIGHT-KD - 15.09376200000001
MOLECULAR-WEIGHT-SEQ - 15.09376200000001
REGULATES - REG0-4827
SYMMETRY - :INVERTED-REPEAT
SYNONYMS - B3481
SYNONYMS - YhhG
SYNONYMS - NikR
//